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[Aspartate aminotransferase--key enzyme in the human systemic metabolism].
Otto-Ślusarczyk D, Graboń W, Mielczarek-Puta M. Otto-Ślusarczyk D, et al. Postepy Hig Med Dosw (Online). 2016 Mar 16;70:219-30. doi: 10.5604/17322693.1197373. Postepy Hig Med Dosw (Online). 2016. PMID: 27117097 Free article. Review. Polish.
There are two aspartate aminotransferase isoforms--cytoplasmic (AST1) and mitochondrial (AST2), that usually occur together and interact with each other metabolically. ...The article is devoted the role of AST, known primarily as a diagnostic liver enzyme, in metabo …
There are two aspartate aminotransferase isoforms--cytoplasmic (AST1) and mitochondrial (AST2), that usually occur together and inter …
Coronavirus disease (COVID-19) and the liver: a comprehensive systematic review and meta-analysis.
Kumar-M P, Mishra S, Jha DK, Shukla J, Choudhury A, Mohindra R, Mandavdhare HS, Dutta U, Sharma V. Kumar-M P, et al. Hepatol Int. 2020 Sep;14(5):711-722. doi: 10.1007/s12072-020-10071-9. Epub 2020 Jul 4. Hepatol Int. 2020. PMID: 32623633 Free PMC article.
BACKGROUND: Liver function derangements have been reported in coronavirus disease (COVID-19), but reported rates are variable. ...Also estimates for overall/total liver disease (TLD) and chronic liver disease (CLD) amongst COVID-19 patients are depicted in a, …
BACKGROUND: Liver function derangements have been reported in coronavirus disease (COVID-19), but reported rates are variable. ...Als …
Alterations of hepatic gluconeogenesis and amino acid metabolism in CTRP3-deficient mice.
Maeda T. Maeda T. Mol Biol Rep. 2022 Feb;49(2):1617-1622. doi: 10.1007/s11033-021-06969-8. Epub 2021 Nov 23. Mol Biol Rep. 2022. PMID: 34811637
METHODS AND RESULTS: Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were increased in 20-h-fasted standard chow-fed Ctrp3 KO mice compared with wild-type (WT) controls. RT-qPCR analysis revealed that ALT1, AST2, and glucose-6-phosphatase m …
METHODS AND RESULTS: Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were increased in 20-h-fasted standard …
Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.
Qin S, Zhou Y, Gray L, Kusebauch U, McEvoy L, Antoine DJ, Hampson L, Park KB, Campbell D, Caballero J, Glusman G, Yan X, Kim TK, Yuan Y, Wang K, Rowen L, Moritz RL, Omenn GS, Pirmohamed M, Hood L. Qin S, et al. J Proteome Res. 2016 Oct 7;15(10):3724-3740. doi: 10.1021/acs.jproteome.6b00547. Epub 2016 Sep 19. J Proteome Res. 2016. PMID: 27575953
We used selected reaction monitoring (SRM) mass spectrometry to quantify 81 liver-enriched proteins plus three aminotransferases (ALT1, AST1, and AST2) in plasma of C57BL/6J and NOD/ShiLtJ mice exposed to acetaminophen or carbon tetrachloride. Plasma concentrations …
We used selected reaction monitoring (SRM) mass spectrometry to quantify 81 liver-enriched proteins plus three aminotransferases (ALT …
Trajectories of hepatic and coagulation dysfunctions related to a rapidly fatal outcome among hospitalized patients with dengue fever in Tainan, 2015.
Yeh CY, Lu BZ, Liang WJ, Shu YC, Chuang KT, Chen PL, Ko WC, Ko NY. Yeh CY, et al. PLoS Negl Trop Dis. 2019 Dec 5;13(12):e0007817. doi: 10.1371/journal.pntd.0007817. eCollection 2019 Dec. PLoS Negl Trop Dis. 2019. PMID: 31805088 Free PMC article.

Both AST and ALT values of the fatal group were significantly higher than those of the survivor group from Day 3 (AST median, 624 U/L vs. 60 U/L, p < 0.001; ALT median, 116 U/L vs. 29 U/L, p = 0.01) of illness onset and peaked on Day 6 (AST median, 9805 U/L vs. 90 U/L, p <

…
Both AST and ALT values of the fatal group were significantly higher than those of the survivor group from Day 3 (AST median, 624 U/L vs. 60 …
Concurrent changes in thermal tolerance thresholds and cellular heat stress response reveals novel molecular signatures and markers of high temperature acclimation in rainbow trout.
Pandey A, Rajesh M, Baral P, Sarma D, Tripathi PH, Akhtar MS, Ciji A, Dubey MK, Pande V, Sharma P, Kamalam BS. Pandey A, et al. J Therm Biol. 2021 Dec;102:103124. doi: 10.1016/j.jtherbio.2021.103124. Epub 2021 Nov 3. J Therm Biol. 2021. PMID: 34863487
Based on the time-course of mRNA expression, the studied markers could be categorized into those which were persistently elevated (hsp70a, hsp70b, hspa5, hsp90a, hsp90b, stip1 and serpinh1 in kidney and hsp90b in liver); those which concurred with changes in CT(min) (hspbp …
Based on the time-course of mRNA expression, the studied markers could be categorized into those which were persistently elevated (hsp70a, h …
Diagnosis and management of hemochromatosis.
Tavill AS; American Association for the Study of Liver Diseases; American College of Gastroenterology; American Gastroenterological Association. Tavill AS, et al. Hepatology. 2001 May;33(5):1321-8. doi: 10.1053/jhep.2001.24783. Hepatology. 2001. PMID: 11343262 No abstract available.